Entries by Katy

Deep Learning-Based Photoacoustic Visual Servoing: Using Outputs from Raw Sensor Data as Inputs to a Robot Controller

Tool tip visualization is an essential component of multiple robotic surgical and interventional procedures. In this paper, we introduce a real-time photoacoustic visual servoing system that processes information directly from raw acoustic sensor data, without requiring image formation or segmentation in order to make robot path planning decisions to track and maintain visualization of tool […]

The feasibility study of the transmission mode photoacoustic measurement of human calcaneus bone in vivo

The photoacoustic (PA) technique is uniquely positioned for biomedical applications primarily due to its ability to visualize optical absorption contrast in deep tissue at ultrasound resolution. In this work, via both three-dimensional (3D) numerical simulations and in vivo experiments on human subjects, we investigated the possibility of PA measurement of human calcaneus bones in vivo in a non-invasive manner, as well as its […]

Anti-HER2 PLGA-PEG polymer nanoparticle containing gold nanorods and paclitaxel for laser-activated breast cancer detection and therapy

Phase-transition nanoparticles have been identified as effective theragnostic, anti-cancer agents. However, non-selective delivery of these agents results in inaccurate diagnosis and insufficient treatment. In this study, we report on the development of targeted phase-transition polymeric nanoparticles (NPs) for the imaging and treatment of breast cancer cell lines over-expressing human epidermal growth factor receptor 2 (HER2). […]

IVUSIVPA hybrid intravascular molecular imaging of angiogenesis in atherosclerotic plaques via RGDfk peptide-targeted nanoprobes

Current intravascular imaging modalities face hurdles in the molecular evaluation of progressed plaques. This study aims to construct a novel hybrid imaging system (intravascular ultrasound/intravascular photoacoustic, IVPA/IVUS) via RGDfk peptide-targeted nanoparticles for monitoring angiogenesis in progressed atherosclerotic plaques in a rabbit model. An atherosclerotic rabbit model was induced by abdominal aorta balloon de-endothelialization followed by a high-fat diet. A human serum albumin (HSA)-based nanoprobe modified with RGDfk […]

Spherical-matching hyperbolic-array photoacoustic computed tomography

Linear-array photoacoustic computed tomography (LA-PACT), for its flexibility and simplicity, has great potential in providing anatomical and functional information of tissues. However, the limited coverage view impedes the LA-PACT obtaining high-quality images. In this study, a photoacoustic tomographic system with a hyperbolic-array transducer was developed for stereoscopic PA imaging of carotid artery. The hyperbolic-array PACT […]

Classification and discrimination of real and fake blood based on photoacoustic spectroscopy combined with particle swarm optimized wavelet neural networks

In this work, photoacoustic spectroscopy was employed to distinguish real blood from fake blood rapidly, accurately, and recoverably. To achieve this goal, a photoacoustic detection system for blood was established in the forward mode. In the experiments, four kinds of animal blood and two kinds of fake blood in a total of 150 groups were used. The […]

Prostate cancer identification via photoacoustic spectroscopy and machine learning

Photoacoustic spectroscopy can generate abundant chemical and physical information about biological tissues. However, this abundance of information makes it difficult to compare these tissues directly. Data mining methods can circumvent this problem. We describe the application of machine-learning methods (including unsupervised hierarchical clustering and supervised classification) to the diagnosis of prostate cancer by photoacoustic spectrum analysis. We focus on the content and distribution of […]

Study the effect of the skull in light illumination and ultrasound detection paths in transcranial photoacoustic imaging

Skull tissue greatly degrades the photoacoustic signal in a transcranial photoacoustic imaging system. In this study, we investigate the feasibility of transcranial photoacoustic imaging, by studying the effect of skull in both illumination path and acoustic detection path, and determine the maximum skull thickness through which accurate photoacoustic imaging is feasible without any post processing. […]