Water clusters and mixed formic acid-water clusters produced in molecular beam have been tagged by one sodium atom and investigated by mass spectrometry and tunable UV laser photoionization. Two series of clusters Na-(H2O)n and Na-(HCOOH)(H2O)n have been detected at various photon energies, from their appearance threshold in the mass spectrum up to 0.5 eV above. The appearance […]
A multimodal workflow for mass spectrometry imaging was developed that combines MALDI imaging with protein identification and quantification by liquid chromatography tandem mass spectrometry (LC-MS/MS). Thin tissue sections were analyzed by MALDI imaging, and the regions of interest (ROI) were identified using a smoothing and edge detection procedure. A midinfrared laser at 3-μm wavelength was […]
A new ion mobility (IM) spectrometer, enabling mobility measurements in the pressure range between 5 and 500 mbar and in the reduced field strength range E/N of 5–90 Td, was developed and characterized. Reduced mobility (K0) values were studied under low E/N (constant value) as well as high E/N (deviation from low field K0) for […]
Infrared matrix-assisted laser desorption ionization (IR-MALDESI) is an ambient mass spectrometry imaging (MSI) technique that relies on electrospray ionization (ESI) for ion generation of desorbed neutrals. Although many mechanisms in IR-MALDESI have been studied in depth, there has not yet been a comprehensive study of how the ESI parameters change the profiles of tissue specific […]
Mass spectrometry imaging of young seedlings is an invaluable tool in understanding how mutations affect metabolite accumulation in plant development. However, due to numerous biological considerations, established methods for the relative quantification of analytes using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging are not viable options. In this study, we report a […]
Chemical exposures can adversely impact fetal development. For many compounds, including common flame retardants, the mechanisms by which this occurs remain unclear, but emerging evidence suggests that disruption at the level of the placenta may play a role. Understanding how the placenta might be vulnerable to chemical exposures is challenging due to its complex structure. […]
Analysis of drugs in hair by mass spectrometry imaging (MSI) has great potential as an objective, long-term measure of medication adherence. However, the fidelity of the chemical record in hair may be compromised by any cosmetic hair treatments. Here, we investigate infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) MSI response to multiple antiretrovirals (ARVs) in […]
Dr. Raiyan Zaman is an Assistant Professor in the Department of Radiology at Harvard Medical School and an Assistant Investigator at the Gordon Center for Medical Imaging at Massachusetts General Hospital. She did her Ph.D. work at the University of Texas at Austin where her focus was Biomedical Engineering Instrumentation. Dr. Zaman also did […]
Dr. Kevin Braeckmans is a Professor at Ghent University in Belgium where he leads the Bio-Photonics Research Group. He received his PhD in Physics at Ghent. Dr. Braeckmans’ group researches advanced optical microscopy methods for pharmaceutical applications, focusing on functional nanomaterials. He also has an interest in developing optics-based methods for drug delivery and […]
Kristie Huda is a Graduate Research Assistant and Ph.D. student at Tulane University. Ms. Huda has a background in Electrical Engineering and her Ph.D. work centers around Biomedical Engineering. Kristie is passionate about developing biomedical applications that will improve women’s health. Her research focuses on developing new imaging methods to study the dynamics of physiological […]