Entries by Katy

A GPU approach to real-time coherence-based photoacoustic imaging and its application to photoacoustic visual servoing

Vision-based robotic control (also known as visual servoing) is promising for surgical tool tip tracking and automated visualization of photoacoustic targets during interventional procedures. However, reliable segmenta- tion in photoacoustic-based visual servoing was previously achieved with a light source that exceeds laser safety limits, due to the limited availability of laser safety limits for only […]

[HTML] Lipid-weighted intraoperative photoacoustic tomography of breast tumors: Volumetric comparison to preoperative MRI

Our group developed an Intraoperative Photoacoustic Screening (iPAS) soft tissue scanner featuring high bulk tissue sensitivity, a clinically compatible scan-time of 6 min, imaging depths greater than 2 cm and the capability to visualize whole breast tumors based on their lipid, rather than hemoglobin, profile. Here, we report on the first clinical experience with breast […]

Monte Carlo simulation for improving spectral photoacoustic imaging-based oxygen saturation estimation of human placental tissue

Using spectral photoacoustic imaging (sPAI) to estimate oxygen saturation of tissue at depth suffers from inaccuracies due to the unknown optical absorption and scattering properties of tissue. Because of the high scattering and absorption of light by tissue, the estimation of concentrations of Hb and HbO2 from the measured photoacoustic (PA) signal intensity can be […]

Deep tissue photoacoustic imaging of nickel (II) dithiolene-containing polymeric nanoparticles in the second near-infrared window

Photoacoustic imaging is gaining great attention in the medical world due to its significant potential for clinical translation. Light excitation in the second near-infrared (NIR-II) window (1000-1350 nm) has resolution and penetration depth suitable for several clinical applications. However, the significant challenge exists for clinical translation because of the absence of notable intrinsic chromophores in […]

Photoacoustic Imaging to Track Magnetic-manipulated Micro-Robots in Deep Tissue

The next generation of intelligent robotic systems has been envisioned as micro-scale mobile and externally controllable robots. Visualization of such small size microrobots to track their motion in nontransparent medium such as human tissue remains a major challenge, limiting translation into clinical applications. Herein, we present a novel, non-invasive, real-time imaging method by integrating ultrasound […]

Photoacoustic detection of glucose based on the pulsed laser induced ultrasonic combined with scanning position method

In order to accurately measure the glucose concentration, the photoacoustic spectroscopy combined with the scanning position method was used in this paper. Meanwhile, a kind of custom-built photoacoustic detection system was established. In this system, a 532nm pumped OPO pulsed laser was used as the excitation source, and a non-focused ultrasonic detector was used to […]

Deep learning-enhanced LED-based photoacoustic imaging

Photoacoustic imaging holds promise in wide range of clinical and preclinical applications. Since photoacoustic imaging can be implemented in a conventional ultrasound scanner by adding light illumination, it is straight forward to realize dual-mode imaging offering complementary contrast. We recently developed an LED-based photoacoustic and ultrasound imaging system (AcousticX) with unprecedented 2D and 3D functional […]

Deep Learning for Image Processing and Reconstruction to Enhance LED-Based Photoacoustic Imaging

hotoacoustic imaging is a rapidly growing imaging technique which combines the best of optical and ultrasound imaging. For the clinical translation of photoacoustic imaging, a lot of steps are being taken and different parameters are being continuously improved. Improvement in image reconstruction, denoising and improvement of resolution are important especially for photoacoustic images obtained from […]

Photostability enhancement of silica-coated gold nanostars for photoacoustic imaging guided photothermal therapy

Gold nanostars (GNSs) are promising contrast agents for simultaneous photothermal therapy and photoacoustic imaging (PAI) owing to their excellent photothermal conversion efficiency. However, GNSs are easily reshaped under transient high-intensity laser pulses, which can cause a rapid shift in the light absorption peak, resulting in a decrease in both therapeutic and monitoring effects. In this work, we synthesized GNSs without toxic […]

Characterizing the aggressiveness of prostate cancer using an all-optical needle photoacoustic sensing probe: feasibility study

In our previous studies, we have developed a prototype interstitial needle sensing probe that can acquire broadband A-line photoacoustic (PA) signals encoding both tissue microarchitecture and histochemical information comparable to that accessible by histology. Paving the road toward clinical translation of this technology, we replaced the piezoelectric hydrophone in the needle PA probe with a […]